Systematic investigation of transcription factors critical in the protection against cerebral ischemia by Danhong injection.

ABSTRACT: Systematic investigations of complex pathological cascades during ischemic brain injury help to elucidate novel therapeutic targets against cerebral ischemia. Although some transcription factors (TFs) involved in cerebral ischemia, systematic surveys of their changes during ischemic brain injury have not been reported. Moreover, some multi-target agents effectively protected against ischemic stroke, but their mechanisms, especially the targets of TFs, are still unclear. Therefore, a comprehensive approach by integrating network pharmacology strategy and a new concatenated tandem array of consensus transcription factor response elements method to systematically investigate the target TFs critical in the protection against cerebral ischemia by a medication was first reported, and then applie

SUBMITTER: Wei J 

PROVIDER: S-EPMC4949467 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature