Sensorimotor processing for balance in spinocerebellar ataxia type 6.

ABSTRACT:

Background

We investigated whether balance impairments caused by cerebellar disease are associated with specific sensorimotor processing deficits that generalize across all sensory modalities. Experiments focused on the putative cerebellar functions of scaling and coordinate transformation of balance responses evoked by stimulation of single sensory channels.

Methods

Vestibular, visual, and proprioceptive sensory channels were stimulated in isolation using galvanic vestibular stimulation, moving visual scenery, and muscle vibration, respectively, in 16 subjects with spinocerebellar ataxia type 6 (SCA6) and 16 matched healthy controls. Two polarities of each stimulus type evoked postural responses of similar form in the forward and backward directions. Disease severity was as

SUBMITTER: Bunn LM 

PROVIDER: S-EPMC4949507 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature