On Modelling Minimal Disease Activity.

ABSTRACT:

Objective

To explore methods for statistical modelling of minimal disease activity (MDA) based on data from intermittent clinic visits.

Methods

The analysis was based on a 2-state model. Comparisons were made between analyses based on "complete case" data from visits at which MDA status was known, and the use of hidden model methodology that incorporated information from visits at which only some MDA defining criteria could be established. Analyses were based on an observational psoriatic arthritis cohort.

Results

With data from 856 patients and 7,024 clinic visits, analysis was based on virtually all visits, although only 62.6% provided enough information to determine MDA status. Estimated mean times for an episode of MDA varied from 4.18 years to 3.10 years, with sm

SUBMITTER: Jackson CH 

PROVIDER: S-EPMC4949508 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature