Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection.

ABSTRACT:

Background

Chronic hepatitis C virus (HCV) infection of the liver with either genotype 1 or genotype 3 gives rise to distinct pathologies, and the two viral genotypes respond differently to antiviral therapy.

Methods

To understand these clinical differences, we compared gene transcription profiles in liver biopsies from patients infected with either gt1 or gt3, and uninfected controls.

Results

Gt1-infected biopsies displayed elevated levels of transcripts regulated by type I and type III interferons (IFN), including genes that predict response to IFN-α therapy. In contrast, genes controlled by IFN-γ were induced in gt3-infected biopsies. Moreover, IFN-γ levels were higher in gt3-infected biopsies. Analysis of hepatocyte-derived cell lines confirmed that the genes upre

SUBMITTER: Robinson MW 

PROVIDER: S-EPMC4949513 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature