EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans.

ABSTRACT:

Objective

Rapid eye movement (REM) sleep has a suppressing effect on epileptic activity. This effect might be directly related to neuronal desynchronization mediated by cholinergic neurotransmission. We investigated whether interictal epileptiform discharges (IEDs) and high frequency oscillations-a biomarker of the epileptogenic zone-are evenly distributed across phasic and tonic REM sleep. We hypothesized that IEDs are more suppressed during phasic REM sleep because of additional cholinergic drive.

Methods

Twelve patients underwent polysomnography during long-term combined scalp-intracerebral electroencephalography (EEG) recording. After sleep staging in the scalp EEG, we identified segments of REM sleep with rapid eye movements (phasic REM) and segments of REM sleep withou

SUBMITTER: Frauscher B 

PROVIDER: S-EPMC4949560 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature