Expanding the phenotypic associations of globular glial tau subtypes.

ABSTRACT:

Introduction

Clinicopathologic correlation in non-Alzheimer's tauopathies is variable, despite refinement of pathologic diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathologic correlation.

Methods

Confirmed GGT cases (n = 11) were identified from 181 frontotemporal tauopathy cases. Clinical and neuroimaging details were collected, and cases sub-typed according to the consensus criteria for GGT diagnosis. Relationships between clinical syndrome and GGT subtype were investigated.

Results

In total, 11 patients (seven males, four females, mean age = 67.3 +/- 10.6 years) with GGT were included. Most, bu

SUBMITTER: Burrell JR 

PROVIDER: S-EPMC4949736 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature