Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis.

ABSTRACT:

Objectives

To evaluate the presence of antibodies to conformation-intact myelin oligodendrocyte glycoprotein (MOG) in a subgroup of adult patients with clinically definite multiple sclerosis (MS) preselected for a specific clinical phenotype including severe spinal cord, optic nerve, and brainstem involvement.

Methods

Antibodies to MOG were investigated using a cell-based assay in 3 groups of patients: 104 preselected patients with MS (group 1), 55 age- and sex-matched, otherwise unselected patients with MS (group 2), and in 22 brain-biopsied patients with demyelinating diseases of the CNS (n = 19 with MS), 4 of whom classified as MS type II (group 3). Recognized epitopes were identified with mutated variants of MOG.

Results

Antibodies to MOG were found in about 5% (5

SUBMITTER: Spadaro M 

PROVIDER: S-EPMC4949775 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature