Quantifying patterns of brain activity: Distinguishing unaffected siblings from participants with ADHD and healthy individuals.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable psychiatric disorders. While previous studies have focussed on mapping focal or connectivity differences at the group level, the present study employed pattern recognition to quantify group separation between unaffected siblings, participants with ADHD, and healthy controls on the basis of spatially distributed brain activations. This was achieved using an fMRI-adapted version of the Stop-Signal Task in a sample of 103 unaffected siblings, 184 participants with ADHD, and 128 healthy controls. We used activation maps derived from three task regressors as features in our analyses employing a Gaussian process classifier. We showed that unaffected siblings could be distinguished from participants with AD

SUBMITTER: Wolfers T 

PROVIDER: S-EPMC4950173 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature