Dataset Information

Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

ABSTRACT:

Objectives

To conduct a geographically defined, UK-based case-control study, to examine any association between physical activity (PA) and amyotrophic lateral sclerosis (ALS).

Methods

A novel historical PA questionnaire was designed, validated, and subsequently administered in individual face-to-face interviews of 175 newly diagnosed sporadic ALS cases and 317 age- and sex-matched community controls. Historical PA energy expenditure and time spent in vigorous-intensity PA were derived from questionnaire data and compared between cases and controls.

Results

Participation in an extra 10kJ/kg/day of PA (equivalent to approximately 45minutes brisk walking) was consistently associated with an increased risk of ALS, with the strongest association observed for adulthood exercise-related PA (OR 1.47, 95% CI 1.10-1.97). An extra 10mins/day of vigorous PA was also associated with the odds of ALS (OR 1.03, 95% CI 1·01-1·05). Results were slightly attenuated following adjustment for smoking and educational attainment.

Conclusions

To our knowledge this is the first study to demonstrate a positive association between ALS and PA participation using a specifically designed and validated historical PA questionnaire. Despite the well-established health benefits of PA, a high activity lifestyle may also be associated with elevated risk of ALS. Large-scale prospective studies in the future may help to confirm this association.

SUBMITTER: Harwood CA

PROVIDER: S-EPMC4950417 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature

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Publications

Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

Harwood Ceryl A CA Westgate Kate K Gunstone Sue S Brage Soren S Wareham Nicholas J NJ McDermott Christopher J CJ Shaw Pamela J PJ

Amyotrophic lateral sclerosis & frontotemporal degeneration 20160321 5-6

<h4>Objectives</h4>To conduct a geographically defined, UK-based case-control study, to examine any association between physical activity (PA) and amyotrophic lateral sclerosis (ALS).<h4>Methods</h4>A novel historical PA questionnaire was designed, validated, and subsequently administered in individual face-to-face interviews of 175 newly diagnosed sporadic ALS cases and 317 age- and sex-matched community controls. Historical PA energy expenditure and time spent in vigorous-intensity PA were der ...[more]

PMID: 26998882

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Dataset Information

Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

Objectives

Methods

Results

Conclusions

Publications

Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis?

Similar Datasets

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