Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins.

ABSTRACT:

Background

Major histocompatibility complex class I (MHCI) proteins present antigenic peptides for immune surveillance and play critical roles in nervous system development and plasticity. Most MHCI are transmembrane proteins. The extracellular domain of MHCI interacts with immunoreceptors, peptides, and co-receptors to mediate immune signaling. While the cytoplasmic domain also plays important roles in endocytic trafficking, cross-presentation of extracellularly derived antigens, and CTL priming, the molecular mediators of cytoplasmic signaling by MHCI remain largely unknown.

Results

Here we show that the cytoplasmic domain of MHCI contains putative protein-protein interaction domains known as PDZ (PSD95/disc large/zonula occludens-1) ligands. PDZ ligands are motifs that bi

SUBMITTER: Frietze KK 

PROVIDER: S-EPMC4950430 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature