Cytomembrane ATP-sensitive K⁺ channels in neurovascular unit targets of ischemic stroke in the recovery period.

ABSTRACT: The present study was to analyze the mechanism of cytomembrane ATP-sensitive K⁺ channels (K_ATP) in the neurovascular unit treatment of ischemic stroke in the recovery period. A total of 24 healthy adult male Wistar rats of 5-8 weeks age, weighing 160-200 g were randomly divided into the control (sham-operation group), model, K_ATP blocker and K_ATP opener groups (n=6 rats per group). Nylon cerebral artery occlusion was conducted using nylon monofilament coated with Poly-L-lysine, which was used to produce a cerebral infarction model. After feeding normally for 3 days, 5-hydroxydecanoate (40 mg/Kg), and diazoxide (40 mg/Kg) were injected to the abdominal cavity in the blocker, and opener groups, respectively. The control received an equivalent norma

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4950624 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature