Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes.

ABSTRACT: A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.

SUBMITTER: Sharma HA 

PROVIDER: S-EPMC4950954 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature