Association of Renalase SNPs rs2296545 and rs2576178 with the Risk of Hypertension: A Meta-Analysis.

ABSTRACT:

Background/aims

Two renalase single nucleotide polymorphisms (SNPs) rs2296545 and rs2576178 have been reported to be associated with the susceptibility to hypertension (HT). Given the inconsistent results, we conducted a meta-analysis to assess the association between these two SNPs and the risk of HT.

Methods

Electronic databases were systematically searched to find relevant studies. Subgroup analysis was conducted according to the different concomitant diseases and ethnicities in the study population. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using fixed-effect or random-effect models.

Results

A total of six case-control studies on rs2296545 and six studies on rs2576178 were included. In the combined analysis, results showed a signifi

SUBMITTER: Lv YB 

PROVIDER: S-EPMC4951046 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature