Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.

ABSTRACT:

Objective

The purpose of this study was to explore the association between single nucleotide polymorphisms (SNPs) in the phospholipase A2 (PLA2), group XIIA gene (PLA2G12A) and schizophrenia.

Methods

This study included 1,063 schizophrenia patients and 1,103 healthy controls from a Han Chinese Population in Northeast China. Four tagSNPs (rs11728699 in intron 1, synonymous rs2285714 in exon 3, rs3087494 in the 3' UTR, and rs7694620 in the downstream region) in PLA2G12A were selected, and they were genotyped by the MALDI-TOF-MS technology. The Chi-square (χ2) test and haplotype analysis were performed to analyze the association of PLA2G12A SNPs and schizophrenia using the software packages SPSS 16.0 and Haploview 4.2.

Results

Among the four tagSNPs, only SNP rs3087494 i

SUBMITTER: Yang G 

PROVIDER: S-EPMC4951095 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature