Analysis of Gene Expression Profiles in the Human Brain Stem, Cerebellum and Cerebral Cortex.

ABSTRACT: The human brain is one of the most mysterious tissues in the body. Our knowledge of the human brain is limited due to the complexity of its structure and the microscopic nature of connections between brain regions and other tissues in the body. In this study, we analyzed the gene expression profiles of three brain regions-the brain stem, cerebellum and cerebral cortex-to identify genes that are differentially expressed among these different brain regions in humans and to obtain a list of robust, region-specific, differentially expressed genes by comparing the expression signatures from different individuals. Feature selection methods, specifically minimum redundancy maximum relevance and incremental feature selection, were employed to analyze the gene expression profiles. Sequential minima

SUBMITTER: Chen L 

PROVIDER: S-EPMC4951119 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature