Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targets.

ABSTRACT: Because of their ability to induce local immunosuppression and to confer cancer cells with resistance to apoptosis, members of the galectin family are emerging as a new class of actionable targets in cancer. Unfortunately, we have yet to obtain a clear picture of the galectin signatures in cancer cells and the surrounding tumor microenvironment. The aim of this study was to provide the first detailed analysis of the galectin signature in molecular subtypes of breast cancer. Expression signatures of galectins were obtained at the mRNA and protein levels. A particular attention was paid to stromal versus epithelial staining and to subcellular compartmentalization. Analysis of the stromal signature showed that gal-1, -3, -9-positive stroma were preferentially found in triple-negative (TN) and

SUBMITTER: Grosset AA 

PROVIDER: S-EPMC4951281 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature