Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression.

ABSTRACT: It is now well established that the enzymes phosphoinositide 3-kinases (PI3Ks) have a key role in the development and progression of many cancer types and indeed PI3Ks inhibitors are currently being tested in clinical trials. Although eight distinct PI3K isoforms exist, grouped into three classes, most of the evidence currently available are focused on one specific isoform with very little known about the potential role of the other members of this family in cancer. Here we demonstrate that the class II enzyme PI3K-C2β is overexpressed in several human breast cancer cell lines and in human breast cancer specimens. Our data indicate that PI3K-C2β regulates breast cancer cell growth in vitro and in vivo and that PI3K-C2β expression in breast tissues is correlated with the proliferative statu

SUBMITTER: Chikh A 

PROVIDER: S-EPMC4951291 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature