Partial Conservation between Mice and Humans in Olfactory Bulb Interneuron Transcription Factor Codes.

ABSTRACT: The mammalian main olfactory bulb (OB) has a large population of GABAergic inhibitory interneurons that contains several subtypes defined by the co-expression other neurotransmitters and calcium binding proteins. The three most commonly studied OB interneuron subtypes co-express either Calretinin, Calbindin, or Tyrosine hydroxylase (Th). Combinations of transcription factors used to specify the phenotype of progenitors are referred to as transcription factor codes, and the current understanding of transcription factor codes that specify OB inhibitory neuron phenotypes are largely based on studies in mice. The conservation of these transcription factor codes in the human OB, however, has not been investigated. The aim of this study was to establish whether transcription factor codes in OB i

SUBMITTER: Fujiwara N 

PROVIDER: S-EPMC4951497 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature