Dataset Information

Recurrent inactivating RASA2 mutations in melanoma.

ABSTRACT: Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.

SUBMITTER: Arafeh R

PROVIDER: S-EPMC4954601 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Recurrent inactivating RASA2 mutations in melanoma.

Arafeh Rand R Qutob Nouar N Emmanuel Rafi R Keren-Paz Alona A Madore Jason J Elkahloun Abdel A Wilmott James S JS Gartner Jared J JJ Di Pizio Antonella A Winograd-Katz Sabina S Sindiri Sivasish S Rotkopf Ron R Dutton-Regester Ken K Johansson Peter P Pritchard Antonia L AL Waddell Nicola N Hill Victoria K VK Lin Jimmy C JC Hevroni Yael Y Rosenberg Steven A SA Khan Javed J Ben-Dor Shifra S Niv Masha Y MY Ulitsky Igor I Mann Graham J GJ Scolyer Richard A RA Hayward Nicholas K NK Samuels Yardena Y

Nature genetics 20151026 12

Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer. ...[more]

PMID: 26502337

Dataset Information

Recurrent inactivating RASA2 mutations in melanoma.

Publications

Recurrent inactivating RASA2 mutations in melanoma.

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