Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung.

ABSTRACT:

Background

Prostaglandin (PG) D2 is an early-phase mediator in inflammation, but its action and the roles of the 2 D-type prostanoid receptors (DPs) DP1 and DP2 (also called chemoattractant receptor-homologous molecule expressed on T(H)2 cells) in regulating macrophages have not been elucidated to date.

Objective

We investigated the role of PGD2 receptors on primary human macrophages, as well as primary murine lung macrophages, and their ability to influence neutrophil action in vitro and in vivo.

Methods

In vitro studies, including migration, Ca(2+) flux, and cytokine secretion, were conducted with primary human monocyte-derived macrophages and neutrophils and freshly isolated murine alveolar and pulmonary interstitial macrophages. In vivo pulmonary inflammation was

SUBMITTER: Jandl K 

PROVIDER: S-EPMC4954606 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature