Maintaining Genome Stability in Defiance of Mitotic DNA Damage.

ABSTRACT: The implementation of decisions affecting cell viability and proliferation is based on prompt detection of the issue to be addressed, formulation and transmission of a correct set of instructions and fidelity in the execution of orders. While the first and the last are purely mechanical processes relying on the faithful functioning of single proteins or macromolecular complexes (sensors and effectors), information is the real cue, with signal amplitude, duration, and frequency ultimately determining the type of response. The cellular response to DNA damage is no exception to the rule. In this review article we focus on DNA damage responses in G2 and Mitosis. First, we set the stage describing mitosis and the machineries in charge of assembling the apparatus responsible for chromosome align

SUBMITTER: Ferrari S 

PROVIDER: S-EPMC4954828 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature