Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.

ABSTRACT: Growing evidence indicates that disruption of our internal timing system contributes to the incidence and severity of metabolic diseases, including obesity and type 2 diabetes. This is perhaps not surprising since components of the circadian clockwork are tightly coupled to metabolic processes across the body. In the current study, we assessed the impact of obesity on the circadian system in mice at a behavioural and molecular level, and determined whether pharmacological targeting of casein kinase 1δ and ε (CK1δ/ε), key regulators of the circadian clock, can confer metabolic benefit. We demonstrate that although behavioural rhythmicity was maintained in diet-induced obesity (DIO), gene expression profiling revealed tissue-specific alteration to the phase and amplitude of the molecular clo

SUBMITTER: Cunningham PS 

PROVIDER: S-EPMC4954991 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature