Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas.

ABSTRACT:

Background

Synovial sarcoma (SS) is a soft tissue sarcoma of unknown histogenesis. Most metastatic or unresectable cases are incurable. Novel antitumor agents and precise prognostication are needed for SS patients. The protein forkhead box M1 (FOXM1), which belongs to the FOX family of transcription factors, is considered to be an independent predictor of poor survival in many cancers and sarcomas, but the prognostic implications and oncogenic roles of FOXM1 in SS are poorly understood. Here we examined the correlation between FOXM1 expression and clinicopathologic and prognostic factors, and we investigated the efficacy of FOXM1 target therapy in SS cases.

Methods

Immunohistochemical study of 106 tumor specimens was conducted to evaluate their immunohistochemical expression

SUBMITTER: Maekawa A 

PROVIDER: S-EPMC4955131 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature