Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population.

ABSTRACT:

Background

Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects.

Methods

We analyzed 10 genotype frequencies for following polymorphisms associated with the development of CINV: serotonin 5-HT3 receptors (HTR3); neurokinin-1 receptors (Tachykinin-1 receptors, TACR1); dopamine D2 receptors (DRD2); and catechol-O-methyltransferase (COMT).

Results

All polymorphisms were successfully genotyped in 200 Japanese subjects and were in Hardy-Weinberg equilibrium. Almost all genotype frequencies were similar to those in the HapMap database or in the previous reports, while frequencies for the Y192H polymorphism in TACR1 were different in Japanese subjects from those in a previous report.

SUBMITTER: Goto A 

PROVIDER: S-EPMC4955237 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature