Intravenous immunoglobulin therapy for small fiber neuropathy: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Small fiber neuropathy is the most common cause of neuropathic pain in peripheral neuropathies, with a minimum prevalence of 53/100,000. Patients experience excruciating pain, and currently available anti-neuropathic and other pain drugs do not relieve the pain substantially. Several open-label studies have suggested an immunological basis in small fiber neuropathy and have reported efficacy of treatment with intravenous immunoglobulin. Therefore, immunological mechanisms conceivably may play a role in small fiber neuropathy. To date, no randomized controlled study with intravenous immunoglobulin in patients with small fiber neuropathy has been performed.

Methods/design

This study is a randomized, double-blind, placebo-controlled, clinical trial in patients with i

SUBMITTER: de Greef BT 

PROVIDER: S-EPMC4955261 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature