Ontology highlight
ABSTRACT:
SUBMITTER: Foshay KM
PROVIDER: S-EPMC4955287 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Molecular cell 20120322 2
It is a long-held paradigm that cell fusion reprograms gene expression but the extent of reprogramming and whether it is affected by the cell types employed remain unknown. We recently showed that the silencing of somatic genes is attributable to either trans-acting cellular environment or cis-acting chromatin context. Here, we examine how trans- versus cis-silenced genes in a somatic cell type behave in fusions to another somatic cell type or to embryonic stem cells (ESCs). We demonstrate that ...[more]