Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial.

ABSTRACT:

Importance

Protocolized sedation improves clinical outcomes in critically ill adults, but its effect in children is unknown.

Objective

To determine whether critically ill children managed with a nurse-implemented, goal-directed sedation protocol experience fewer days of mechanical ventilation than patients receiving usual care.

Design, setting, and participants

Cluster randomized trial conducted in 31 US pediatric intensive care units (PICUs). A total of 2449 children (mean age, 4.7 years; range, 2 weeks to 17 years) mechanically ventilated for acute respiratory failure were enrolled in 2009-2013 and followed up until 72 hours after opioids were discontinued, 28 days, or hospital discharge.

Intervention

Intervention PICUs (17 sites; n = 1225 patients) used a pr

SUBMITTER: Curley MA 

PROVIDER: S-EPMC4955566 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature