Selective Mapping of Psychopathy and Externalizing to Dissociable Circuits for Inhibitory Self-Control.

ABSTRACT: Antisociality is commonly conceptualized as a unitary construct, but there is considerable evidence for multidimensionality. In particular, two partially dissociable symptom clusters - psychopathy and externalizing - have divergent associations to clinical and forensic outcomes and are linked to unique patterns executive dysfunction. Here, we used fMRI in a sample of incarcerated offenders to map these dimensions of antisocial behavior to brain circuits underlying two aspects of inhibitory self-control: interference suppression and response inhibition. We found that psychopathy and externalizing are characterized by unique and task-selective patterns of dysfunction. While higher levels of psychopathy predicted increased activity within a distributed fronto-parietal network for interference

SUBMITTER: Rodman AM 

PROVIDER: S-EPMC4955633 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature