BDNF Val66Met Polymorphism as a Moderator of Exercise Enhancement of Smoking Cessation Treatment in Anxiety Vulnerable Adults.

ABSTRACT:

Background

Exercise interventions facilitate odds of quit success among high-anxiety sensitive adults smokers. We examined the dependency of these benefits on the genetic BDNF Val66Met (rs6265) polymorphism; individuals who are Met carriers have lower BDNF responses and reduced associated benefits from exercise. Accordingly, we hypothesized that the efficacy of vigorous exercise for smoking cessation would be specific to high-anxiety sensitive Val/Val carriers.

Methods

Participants were adults (N=55) of European ancestry who had participated in a randomized controlled trial comparing a smoking cessation program augmented with exercise vs. augmented with a wellness control treatment. In this secondary analysis, growth curve models for point-prevalence abstinence (PPA)

SUBMITTER: Smits JA 

PROVIDER: S-EPMC4955634 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature