Gut microbiota in early pediatric multiple sclerosis: a case-control study.

ABSTRACT:

Background and purpose

Alterations in the gut microbial community composition may be influential in neurological disease. Microbial community profiles were compared between early onset pediatric multiple sclerosis (MS) and control children similar for age and sex.

Methods

Children ≤18 years old within 2 years of MS onset or controls without autoimmune disorders attending a University of California, San Francisco, USA, pediatric clinic were examined for fecal bacterial community composition and predicted function by 16S ribosomal RNA sequencing and phylogenetic reconstruction of unobserved states (PICRUSt) analysis. Associations between subject characteristics and the microbiota, including beta diversity and taxa abundance, were identified using non-parametric tests, permutat

SUBMITTER: Tremlett H 

PROVIDER: S-EPMC4955679 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature