Screening dietary flavonoids for the reversal of P-glycoprotein-mediated multidrug resistance in cancer.

ABSTRACT: P-Glycoprotein (P-gp) serves as a therapeutic target for the development of inhibitors to overcome multidrug resistance in cancer cells. Although various screening procedures have been practiced so far to develop first three generations of P-gp inhibitors, their toxicity and drug interaction profiles are still a matter of concern. To address the above important problem of developing safe and effective P-gp inhibitors, we have made systematic computational and experimental studies on the interaction of natural phytochemicals with human P-gp. Molecular docking and QSAR studies were carried out for 40 dietary phytochemicals in the drug-binding site of the transmembrane domains (TMDs) of P-gp. Dietary flavonoids exhibit better interactions with homology modeled human P-gp. Based on the computa

SUBMITTER: Mohana S 

PROVIDER: S-EPMC4955727 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature