A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2.

ABSTRACT:

Background

Calabadion 2 is a new drug-encapsulating agent. In this study, the authors aim to assess its utility as an agent to reverse general anesthesia with etomidate and ketamine and facilitate recovery.

Methods

To evaluate the effect of calabadion 2 on anesthesia recovery, the authors studied the response of rats to calabadion 2 after continuous and bolus intravenous etomidate or ketamine and bolus intramuscular ketamine administration. The authors measured electroencephalographic predictors of depth of anesthesia (burst suppression ratio and total electroencephalographic power), functional mobility impairment, blood pressure, and toxicity.

Results

Calabadion 2 dose-dependently reverses the effects of ketamine and etomidate on electroencephalographic predictors of

SUBMITTER: Diaz-Gil D 

PROVIDER: S-EPMC4955735 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature