RF-Hydroxysite: a random forest based predictor for hydroxylation sites.

ABSTRACT: Protein hydroxylation is an emerging posttranslational modification involved in both normal cellular processes and a growing number of pathological states, including several cancers. Protein hydroxylation is mediated by members of the hydroxylase family of enzymes, which catalyze the conversion of an alkyne group at select lysine or proline residues on their target substrates to a hydroxyl. Traditionally, hydroxylation has been identified using expensive and time-consuming experimental methods, such as tandem mass spectrometry. Therefore, to facilitate identification of putative hydroxylation sites and to complement existing experimental approaches, computational methods designed to predict the hydroxylation sites in protein sequences have recently been developed. Building on these efforts

SUBMITTER: Ismail HD 

PROVIDER: S-EPMC4955772 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature