Family history and the natural history of colorectal cancer: systematic review.

ABSTRACT:

Purpose

Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks.

Methods

We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening.

Results

We found high heterogeneity in family-history definitions, the most common definition being one or more first-degree relatives. The prevalence of family history may be lower than the commonly cited 10%, and confirms evidence for increasing levels of risk associated with increasing family-history burden. There is evidence for higher prevalence of adenomas and of multiple adenomas in people with family history of CRC but no evidence for differential adenoma location or adenoma progress

SUBMITTER: Henrikson NB 

PROVIDER: S-EPMC4955831 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature