Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict.

ABSTRACT: Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers', and fathers' polygenic risk scores for behavioral undercontrol, and mothers' and fathers' interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted

SUBMITTER: Elam KK 

PROVIDER: S-EPMC4955880 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature