Meta-Analysis of Mitochondrial DNA Variation in the Iberian Peninsula.

ABSTRACT: The Iberian Peninsula has been the focus of attention of numerous studies dealing with mitochondrial DNA (mtDNA) variation, most of them targeting the control region segment. In the present study we sequenced the control region of 3,024 Spanish individuals from areas where available data were still limited. We also compiled mtDNA haplotypes from the literature involving 4,588 sequences and 28 population groups or small regions. We meta-analyzed all these data in order to shed further light on patterns of geographic variation, taking advantage of the large sample size and geographic coverage, in contrast with the atomized sampling strategy of previous work. The results indicate that the main mtDNA haplogroups show primarily clinal geographic patterns across the Iberian geography, roughly al

SUBMITTER: Barral-Arca R 

PROVIDER: S-EPMC4956223 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature