Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjogren's Syndrome and Systemic Sclerosis.

ABSTRACT: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which can affect most organ systems including skin, joints and the kidney. Clinically, SLE is a heterogeneous disease and shares features of several other rheumatic diseases, in particular primary Sjögrens syndrome (pSS) and systemic sclerosis (SSc), why it is difficult to diagnose The pathogenesis of SLE is not completely understood, partly due to the heterogeneity of the disease. This study demonstrates that metabolomics can be used as a tool for improved diagnosis of SLE compared to other similar autoimmune diseases. We observed differences in metabolic profiles with a classification specificity above 67% in the comparison of SLE with pSS, SSc and a matched group of healthy individuals. Selected metabolites

SUBMITTER: Bengtsson AA 

PROVIDER: S-EPMC4956266 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature