Elucidating neural network functional connectivity abnormalities in bipolar disorder: toward a harmonized methodological approach.

ABSTRACT: Bipolar disorder (BD), a mood disorder characterized by emotional lability and dysregulation, is associated with alterations in functional connectivity, particularly as assessed using functional MRI. Here, we provide an overview of the extant literature, and themes that have emerged within it. We identified published research describing functional connectivity in BD using PubMed and follow-up searches. The most consistent evidence favors abnormally heightened functional connectivity between the amygdala and the lateral regions of the ventral prefrontal cortex (PFC), both during rest or emotional processing. Altered interactions between the amygdala and more medial PFC regions have been implicated in BD, but are less consistently related to core symptoms and are sometimes associated with mo

SUBMITTER: Chase HW 

PROVIDER: S-EPMC4956344 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature