Isolation of Bioactive Rotenoids and Isoflavonoids from the Fruits of Millettia caerulea.

ABSTRACT: Three new rotenoids (1-3), two new isoflavonoids (4 and 5), and six known analogues (6-11) were isolated from an n-hexane partition of a methanol extract of the fruits of Millettia caerulea, with the structures of the new compounds elucidated by analysis of their spectroscopic data. The relative configurations of the rotenoids were determined by interpretation of their NMR spectroscopic data, and their absolute configurations were established using electronic circular dichroism spectra and specific rotation values. All compounds isolated were evaluated for their cell growth inhibitory activity against the HT-29 human colon cancer cell line, and the known compounds, (-)-3-hydroxyrotenone (6) and (-)-rotenone (7), were found to be potently active. When tested in an NF-κB inhibition assay, co

SUBMITTER: Ren Y 

PROVIDER: S-EPMC4956498 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature