Associations of Oral α-, β-, and γ-Human Papillomavirus Types With Risk of Incident Head and Neck Cancer.

ABSTRACT:

Importance

Prospective studies are needed to examine the temporal relationship between oral human papillomavirus (HPV) detection and risk of head and neck squamous cell carcinoma (HNSCC). Moreover, the oral cavity contains a wide spectrum of α-, β-, and γ-HPV types, but their association with risk of HNSCC is unknown.

Objective

To prospectively examine associations between α-, β-, and γ-HPV detection in the oral cavity and incident HNSCC.

Design

A nested case-control study was carried out among 96 650 participants, cancer free at baseline, with available mouthwash samples in 2 prospective cohort studies: (1) the American Cancer Society Cancer Prevention Study II Nutrition Cohort and (2) the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Incident cases

SUBMITTER: Agalliu I 

PROVIDER: S-EPMC4956584 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature