Ontology highlight
ABSTRACT:
SUBMITTER: Cui N
PROVIDER: S-EPMC4956939 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cui Na N Hao Guimin G Zhao Zhiming Z Wang Feng F Cao Jinfeng J Yang Aimin A
Journal of cellular and molecular medicine 20160421 8
MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems, where their functions include the regulation of self-renewal, cellular differentiation, proliferation and apoptosis. However, the function and mechanisms of individual miRs in regulating spermatogonial stem cell (SSC) homeostasis remain unclear. In the present study, we report for the first time that miR-224 is highly expressed in mouse SSCs. Functional assays using miRNA mimics and inhibitors r ...[more]