Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila.

ABSTRACT: Legionella pneumophila is a causative agent of a severe pneumonia, known as Legionnaires' disease. Legionella pathogenicity is mediated by specific virulence factors, called bacterial effectors, which are injected into the invaded host cell by the bacterial type IV secretion system. Bacterial effectors are involved in complex interactions with the components of the host cell immune and signaling pathways, which eventually lead to bacterial survival and replication inside the mammalian cell. Structural and functional studies of bacterial effectors are, therefore, crucial for elucidating the mechanisms of Legionella virulence. Here we describe the crystal structure of the LpiR1 (Lpg0634) effector protein and investigate the effects of its overexpression in mammalian cells. LpiR1 is an α-heli

SUBMITTER: Beyrakhova KA 

PROVIDER: S-EPMC4957058 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature