HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors.

ABSTRACT: HIV-1 Gag is the master orchestrator of particle assembly. The central role of Gag at multiple stages of the HIV lifecycle has led to efforts to develop drugs that directly target Gag and prevent the formation and release of infectious particles. Until recently, however, only the catalytic site protease inhibitors have been available to inhibit late stages of HIV replication. This review summarizes the current state of development of antivirals that target Gag or disrupt late events in the retrovirus lifecycle such as maturation of the viral capsid. Maturation inhibitors represent an exciting new series of antiviral compounds, including those that specifically target CA-SP1 cleavage and the allosteric integrase inhibitors that inhibit maturation by a completely different mechanism. Numerou

SUBMITTER: Spearman P 

PROVIDER: S-EPMC4957142 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature