Improving total knee arthroplasty perioperative pain management using a periarticular injection with bupivacaine liposomal suspension.

ABSTRACT: Patients undergoing total knee arthroplasty (TKA) report low satisfaction with postoperative pain control. The purpose of this study is to examine if there is a difference in post-operative pain for TKA patients without femoral nerve block receiving an intra-operative pericapsular injection of bupivacaine liposome suspension (EXPAREL; Pacira Pharmaceuticals, Inc., San Diego, California) versus a concentrated multi drug cocktail. Seventy TKA patients were randomly assigned to either the bupivacaine liposome or the multi-drug cocktail. Post-operative pain scores, morphine sulfate equivalence consumption values, adverse events, and overall pain control satisfaction scores were collected. Patients reported significantly higher pain level for the cocktail group on post-op day 1 (p < .05)

SUBMITTER: Snyder MA 

PROVIDER: S-EPMC4957154 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature