A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation.

ABSTRACT:

Unlabelled

Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model. Therefore, dietary sulforaphane supplementation is not a promising candidate for larger scale clinical trials targeting airway inflammation.

Trial registration

NCT01625130 . Registered 19 June, 2012.

SUBMITTER: Duran CG 

PROVIDER: S-EPMC4957339 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature