Effect of in ovo folic acid injection on hepatic IGF2 expression and embryo growth of broilers.

ABSTRACT:

Background

Insulin-like factor 2 (IGF2) plays an important role in embryonic growth process by modulating intermediary metabolism and cell proliferation. Folic acid is involved in one carbon metabolism and contributes to DNA methylation which is related to gene expression. The purpose of this study was to explore whether folic acid could regulate IGF2 expression via epigenetic mechanism and further promote embryonic growth of new-hatched broilers.

Methods

In the present study, 360 fertile eggs were selected and randomly assigned to four treatments. On 11 embryonic day of incubation (E11), 0, 50, 100 and 150 μg folic acid were injected into eggs respectively. After hatched, growth performance of broilers were calculated. Hepatic IGF2 expression, methylation level and chromati

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4957392 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature