Robust Cytokine and Chemokine Response in Nasopharyngeal Secretions: Association With Decreased Severity in Children With Physician Diagnosed Bronchiolitis.

ABSTRACT:

Background

Bronchiolitis causes substantial disease in young children. Previous findings had indicated that a robust innate immune response was not associated with a poor clinical outcome in bronchiolitis. This study tested the hypothesis that increased concentrations of cytokines and chemokines in nasal wash specimens were associated with decreased severity in bronchiolitis.

Methods

Children <24 months old who presented to the emergency department with signs and symptoms of bronchiolitis were eligible for enrollment. Nasal wash specimens were analyzed for viral pathogens and cytokine/chemokine concentrations. These results were evaluated with regard to disposition.

Results

One hundred eleven children with bronchiolitis were enrolled. A viral pathogen was identified i

SUBMITTER: Nicholson EG 

PROVIDER: S-EPMC4957440 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature