The Evolution and Transmission of Epidemic GII.17 Noroviruses.

ABSTRACT:

Background

In recent decades, the GII.4 norovirus genotype has predominated in epidemics worldwide and been associated with an increased rate of evolutionary change. In 2014, a novel GII.17 variant emerged and persisted, causing large outbreaks of gastroenteritis in China and sporadic infections globally. The origin, evolution, and transmission history of this new variant are largely unknown.

Methods

We generated 103 full capsid and 8 whole-genome sequences of GII.17 strains collected between August 2013 and November 2015 in Guangdong, China. Phylogenetic analyses were performed by integrating our data with those for all publically available GII.17 sequences.

Results

The novel emergent lineage GII.17_Kawasaki_2014 most likely originated from Africa around 2001 and evo

SUBMITTER: Lu J 

PROVIDER: S-EPMC4957445 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature