Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study.

ABSTRACT:

Background

Ambient particles have been shown to exacerbate measures of biological aging; yet, no studies have examined their relationships with DNA methylation age (DNAm-age), an epigenome-wide DNA methylation based predictor of chronological age.

Objective

We examined the relationship of DNAm-age with fine particulate matter (PM_2.5), a measure of total inhalable particle mass, and black carbon (BC), a measure of particles from vehicular traffic.

Methods

We used validated spatiotemporal models to generate 1-year PM_2.5 and BC exposure levels at the addresses of 589 older men participating in the VA Normative Aging Study with 1-3 visits between 2000 and 2011 (n = 1032 observations). Blood DNAm-age was calculated using 353 CpG sites from the

SUBMITTER: Nwanaji-Enwerem JC 

PROVIDER: S-EPMC4957520 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature