Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD).

ABSTRACT:

Background

The immune system is a promising therapeutic target for disease modification in Parkinson's disease (PD), but appropriate immune-related biomarkers must be identified to allow patient stratification for trials and tracking of therapeutic effects. The objective of this study was to investigate whether immune markers in peripheral blood are candidate prognostic biomarkers through determining their relationship with disease progression in PD.

Methods

Serum samples were collected in incident PD cases and age-matched controls. Subjects were clinically evaluated at baseline and 18 and 36 months. Ten cytokines and C-reactive protein were measured, with data reduction using principal-component analysis, and relationships between component scores and motor (MDS Unified Par

SUBMITTER: Williams-Gray CH 

PROVIDER: S-EPMC4957620 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature